The Effect of Gum Arabic (GA) on Adult Dialysis Patients in Abu Dhabi: A Prospective Randomized-controlled Trial (The GADAD Study)

Status: Recruiting
Location: See location...
Intervention Type: Dietary supplement, Other
Study Type: Interventional
Study Phase: Phase 1/Phase 2
SUMMARY

Gum Arabic (GA), derived from Acacia trees, has shown potential benefits in metabolic, renal, and inflammatory conditions. This study explores the impact of GA on residual renal function in end-stage renal disease (ESRD) patients undergoing dialysis, as current evidence is limited.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
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⁃ To be eligible to participate in this trial, an individual must meet all the following criteria:

• Men and women ≥18 years of age with diagnosed ESRD and prescribed regular dialysis at least once a week, weekly at least for past two weeks.

• For past two weeks including women of childbearing potential who are currently adopting any method of contraception or have completed the family and undergone sterilization procedures and women of non-childbearing potential.

• Patients with residual renal function - Patients who produce a minimum of 200 ml of urine during a full day of collection (A full day collection: the patient discards the first urine sample on the day of collection then collects all urine for the entire day and night and collects the first urine sample of the next day) r on a non-dialysis long break day.

• Able and willing to complete the whole period of the study (maximum of 266 days from enrolment).

• With the ability to understand the study procedures, the informed consent \& voluntarily sign an informed consent form and be able to comply with the requirements of the protocol.

Locations
Other Locations
United Arab Emirates
SEHA Kidney Care (SKC)
RECRUITING
Abu Dhabi
Contact Information
Primary
Stephen G Holt, MD
sholt@seha.ae
+971 2 711 7444
Backup
Edward R Smith, PhD
esmith@seha.ae
Time Frame
Start Date: 2025-02-03
Estimated Completion Date: 2026-04-30
Participants
Target number of participants: 40
Treatments
Experimental: Treatment A: 30g powdered GA in 100ml water, consumed daily
Treatment A: 30g powdered GA in 100ml water, consumed daily
Other: Treatment B: 100ml water, consumed daily.
Treatment B: 100ml water, consumed daily. Participants will follow their usual medications and lifestyle, randomized into two sequences (AB or BA).
Related Therapeutic Areas
Sponsors
Leads: Abu Dhabi Health Services Company

This content was sourced from clinicaltrials.gov